| 1. | Bufalin, ouabain and digoxin are a few toxic cardiac glycosides.
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| 2. | The glycosylation of ouabagenin to add the rhamnose moiety produced ouabain.
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| 3. | The figure below shows the key steps in the synthesis of ouabain.
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| 4. | E contained all the required functionalities and stereochemistry needed to produce ouabain.
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| 5. | Post asked whether the enzyme was inhibited by ouabain.
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| 6. | Small doses of ouabain can be used to treat hypotension and cardiac arrhythmias.
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| 7. | There is disagreement though on whether or not this endogenous substance actually is ouabain.
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| 8. | The total synthesis of ouabain was achieved in 2008 by Deslongchamps laboratory in Canada.
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| 9. | The structure of E was confirmed by comparison against the degradation product of ouabain.
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| 10. | Ataxia is observed for lower ouabain concentrations, dystonia is observed at higher ouabain concentrations.
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