| 1. | It functions as an inhibitor of fibrinolysis by inhibiting plasmin and kallikrein.
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| 2. | HMWK in turn is cleaved by the enzyme kallikrein to produce bradykinin.
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| 3. | The inhibitor also inactivates kallikrein and plasmin, also involved in blood coagulation.
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| 4. | He named it kallikrein, by derivation from the Greek word for pancreas.
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| 5. | It inhibits proteases like chymotrypsin, kallikrein, plasmin, thrombin, and trypsin.
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| 6. | HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system.
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| 7. | HMWK is also a precursor of bradykinin; this vasodilator is released through positive feedback by kallikrein.
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| 8. | The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein.
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| 9. | KLK9 belongs to the kallikrein subgroup of serine proteases, which have diverse physiologic functions in many tissues.
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| 10. | ACh also causes the salivary gland to release kallikrein, an enzyme that converts kininogen to lysyl-bradykinin.
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