For an exposition & allusion to this mechanism observe that the opioid oxycodone, derived from codeine, is 1.5? 1.7?the analgesic potency of morphine ( an opioid to which codeine is by comparison only 8 % 12 % as potent relatively, or 0.17th its strength in rats ); yet oxycodone's intermediates in its synthesis from codeine are : S ! the potency of codeine ( " i . e . " codeinone ); 0.13 that of morphine ( " i . e . " 14-hydroxycodeine ) in rats and less in mice ( to illustrate : the former even being less than the 0.17 of morphine that codeine is ); with the final possible stand alone intermediate compound between codeine & oxycodone ( " i . e . " 7, 8-dihydrocodeine ) being at most 150 % to 200 % that of codeine.
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