1. Research also has provided new insights to the development of centromeres . 2. The signal for formation of a regional centromere appears to be epigenetic. 3. Both Aurora B and MCAK localize to the inner centromere during prometaphase. 4. In humans, centromere protein B is encoded by the CENPB gene. 5. Centromere protein B is a highly conserved protein that facilitates centromere formation.6. Centromere protein B is a highly conserved protein that facilitates centromere formation. 7. Centromeres are the chromosomal domains that specify the mitotic behavior of chromosomes.8. The constitutive proteins include CENPA ( centromere protein A ), CENPD. 9. During metaphase, the kinetochore microtubules connect to the centromere . 10. The heterochromatic regions are the areas near the centromeres and nucleolar organizers. 
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