Azaserine inhibits the rate limiting step of the metabolic hexosamine pathway and an irreversibly inhibits ?-glutamyltransferase by acting directly at the substrate-binding pocket.
2.
"' Azaserine "'is a naturally occurring serine derivative diazo compound with antineoplastic and antibiotic properties deriving from its action as a purinergic antagonist and structural similarity to glutamine.
3.
Independent of hexosamine pathway inhibition, azaserine has been demonstrated to protect against hyperglycemic endothelial damage by elevating serum concentrations of manganese-superoxide dismutase, directly reducing the concentration of reactive oxygen species.
4.
Azaserine also downregulates the expression of VCAM-1 and ICAM-1 in response to TNF-?, and research indicates that it may have potential in identifying the L-leucine-favoring system transporter in human T-lymphocytes.
5.
""'Streptomyces fragilis " "'is a bacterium species from the genus of " Streptomyces " which has been isolated from soil in Argentina . " Streptomyces fragilis " produces the antibiotic azaserine.
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