CAF-1 contains a PCNA-binding motif, called a PIP-box, that allows CAF-1 to associate with the replisome through PCNA and is able to deposit histone H3-H4 dimers onto newly synthesized DNA . The Rtt106 chaperone is also involved in this process, and associated with CAF-1 and H3-H4 dimers during chromatin formation.
32.
"CCDC113 ", located between nucleotides 58283840 and 58317740 on chromosome 16, is surrounded between antisense genes " PRSS54 " and " CSNK2A2 " and downstream from " GINS3 " and " NDRG4 " on the sense strand . " PRSS54 " is a trypsin-like serine protease which codes for the inactive serine protease 54 precursor . " CSNK2A2 " the casein kinase 2, alpha prime polypeptide contains a protein kinase domain and a catalytic domain . " GINS3 " is essential for the initiation of DNA replication and replisome progression in eukaryotes . " NDRG4 " a member of the " N-myc " downregulated gene family belonging to the alpha / beta hydrolase superfamily which encodes a cytoplasmic protein responsible for cell cycle progression and survival in primary astrocytes and may be involved in regulation of mitogenic signaling in vascular smooth muscle cells.
