In the prefrontal cortex, HK1 putatively forms a protein complex with EAAT2, Na + / K + ATPase, and aconitase, which functions to remove glutamate from the perisynaptic space and maintain low basal levels in the synaptic cleft.
32.
The high efficiency of superoxide dismutase seems necessary : even at the subnanomolar concentrations achieved by the high concentrations of SOD within cells, superoxide inactivates the citric acid cycle enzyme aconitase, can poison energy metabolism, and releases potentially toxic iron.
33.
In other words, when there is high iron in the cell, the iron itself causes the cell to produce more iron storage molecules . ( The IRE-BP is an aconitase; for a schematic drawing of the shape change, see here ).
34.
Examples of the application of this technique in biochemistry include the study of reactions catalyzed by nucleoside diphosphohexose-4, 6-dehydratases, the aconitase-catalyzed elimination of water from citrate, and various reactions catalyzed by coenzyme B 12-dependent enzymes, among others.
35.
I expect wikipedia to have information on everything, there are certainly some not so notable listings such as the aconitase enzyme page, which I imagine was easy to get " notability " for, but will be read far fewer times than this page will . & # 151; ( talk)
36.
Figure legend : blue color = reaction steps of the citric acid cycle; brown color = reaction steps of the malate aspartate shuttle; green color = enzymes overexpressed in tumors . 1 = glutaminase, 2 = GOT, 3 = ?-ketoglutarate dehydrogenase, 4 = succinate dehydrogenase, 5 = fumarase, 6 = malate dehydrogenase, 7a = cytosolic malic enzyme, 7b = mitochondrial malic enzyme, 8 = citrate synthase, 9 = aconitase, 10 = lactate dehydrogenase
