Brand names of animal-derived hyaluronidase include Hydase TM ( developed and manufactured by PrimaPharm Inc ., distributed by Akorn Inc . ), which has been FDA-approved as a " thimerosal-free " animal-derived hyaluronidase, Vitrase ( Bausch + Lomb / Valeant Pharmaceuticals ), Amphadase ( Amphastar Pharmaceuticals ), and Wydase.
22.
The proteins in black mamba venom are of low molecular weight, low viscosity, and the venom's high activity in terms of hyaluronidases, which is also essential in facilitating dispersion of venom toxins throughout tissue ( spreading the venom through the body ) by catalyzing the hydrolysis of hyaluronan, a constituent of the extracellular matrix ( ECM ), hyaluronidase lowers the viscosity of hyaluronan, and Dendroaspin natriuretic peptide ( DNP ), a newly discovered component of mamba venom, is the most-potent natriuretic peptide and it's unique to the genus " Dendroaspis ", or mambas.
